Harry T. Orr

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1

Harry T. Orr, Ming‐Yi Chung, Sandro Banfi et al. · Nature Genetics · 1993 · 1.6K citations

Molecular Neuroscience, Genetics, Molecular Biology +6

Ataxin-1 Nuclear Localization and Aggregation

Ivan A. Klement, Pamela J. Skinner, Michael D. Kaytor et al. · Cell · 1998 · 959 citations · Full text

Nuclear Organization, Nuclear Engineering, Molecular Biology +1

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

Gerard D. Schellenberg, Thomas D. Bird, Ellen M. Wijsman et al. · Science · 1992 · 943 citations

Neurodegenerative Diseases, Disease Locus, Alzheimer's Disease +15

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

Christopher J. Cummings, Michael A. Mancini, Barbara Antalffy et al. · Nature Genetics · 1998 · 742 citations

Protein Function, Protein Assembly, Protein Folding +9

Identification of genes that modify ataxin-1-induced neurodegeneration

Pedro Fernández-Fúnez, María Laura Niño-Rosales, Béatrice Gouyon et al. · Nature · 2000 · 660 citations

Neurodegenerative Diseases, Genetics, Ataxin-1-induced Neurodegeneration +7