Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1

Harry T. Orr, Ming‐Yi Chung, Sandro Banfi, +7

Nature Genetics

Molecular NeuroscienceGeneticsMolecular BiologyMolecular GeneticsNeuroscience +4

Ataxin-1 Nuclear Localization and Aggregation

Ivan A. Klement, Pamela J. Skinner, Michael D. Kaytor, +5

Cell

Nuclear OrganizationNuclear EngineeringMolecular BiologyAtaxin-1 Nuclear Localization

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

Gerard D. Schellenberg, Thomas D. Bird, Ellen M. Wijsman, +10

Science

Neurodegenerative DiseasesDisease LocusAlzheimer's DiseaseGenetic DisorderGenetics +13

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

Christopher J. Cummings, Michael A. Mancini, Barbara Antalffy, +3

Nature Genetics

Protein FunctionProtein AssemblyProtein FoldingNatural SciencesMedicine +7

Identification of genes that modify ataxin-1-induced neurodegeneration

Pedro Fernández-Fúnez, María Laura Niño-Rosales, Béatrice Gouyon, +12

Nature

Neurodegenerative DiseasesGeneticsAtaxin-1-induced NeurodegenerationDegenerative PathologyNeurochemical Biomarkers +5

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

Haibin Xia, Qinwen Mao, Steven Eliason, +7

Nature Medicine

Neurodegenerative DiseasesMolecular NeuroscienceDegenerative PathologyNeuroprotectionNeurology +6

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

Eric N. Burright, H. Brent Clark, Antonio Servadio, +6

Cell

Knockout MouseNeurodegenerative DiseasesDevelopmental BiologyTransgenic Mouse ModelsGenetics +6

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

Pamela J. Skinner, Beena T. Koshy, Christopher J. Cummings, +4

Nature

Protein FunctionSignal TransductionNatural SciencesMolecular BiologyNuclear Organization +4

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

Hidde L. Ploegh, Harry T. Orr, Jack L. Strominger

Cell

HistocompatibilityHlaImmunogeneticsAllergyHuman Leukocyte Antigen +10

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

Daniel E. Geraghty, B H Koller, Harry T. Orr

Proceedings of the National Academy of Sciences

HistocompatibilityGeneticsHla ImmunogeneticsMolecular BiologyMolecular Genetics +17