Concepedia

Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)

Jan M. Woynarowski, Cheryl Napier, Steven K. Koester, Shih-Fong Chen, Dean A. Troyer, William G. Chapman, John R. MacDonald

Biochemical Pharmacology · 1997 · 100 citations · 40 references

DOI

Concepts

References

40

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

A H Wyllie, R. G. Morris, Alex Smith et al. · The Journal of Pathology · 1984 · 1.6K citations

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Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

F Oberhammer, James W. Wilson, Caroline Dive et al. · The EMBO Journal · 1993 · 1.1K citations · Full text

, , +4

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

Wojciech Gorczyca, J Gong, Zbigniew Darżynkiewicz · PubMed · 1993 · 994 citations

, , +14

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

Patricia M. Takahara, Amy C. Rosenzweig, Christin Frederick et al. · Nature · 1995 · 767 citations

, , +15

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.

W. David Jarvis, Amy Turner, Lawrence F. Povirk et al. · PubMed · 1994 · 355 citations

, , +16