Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

Hiroshi Kase, Kazuyuki Iwahashi, Satoshi Nakanishi et al. · Biochemical and Biophysical Research Communications · 1987 · 942 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

Roger Y. Tsien, T J Rink, Martin Poenie · Cell Calcium · 1985 · 655 citations

Natural Sciences, Biophysics, Cell Biology +17

Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators.

Maria Halbrügge, Claudia B Friedrich, Martin Eigenthaler et al. · Journal of Biological Chemistry · 1990 · 271 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation.

Wolfgang Siess, Frances Lea Siegel, E G Lapetina · Journal of Biological Chemistry · 1983 · 204 citations · Full text

Life Sciences, Pharmacology, Cell Signaling +15