Comparative studies of the metabolic activation of chrysene in rodent and human skin

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. Brookes, P.D. Lawley · Nature · 1964 · 678 citations

Pharmacy, Molecular Biology, Toxicology +17

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

Eliezer Huberman, Leo Sachs, Shen K. Yang et al. · Proceedings of the National Academy of Sciences · 1976 · 480 citations · Full text

Pharmacy, Toxicology, Carcinogenesis +16

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

Dhiren R. Thakker, Haruhiko Yagi, H. Akagi et al. · Chemico-Biological Interactions · 1977 · 262 citations

Medicine, Chemistry, Pharmacology +12

Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.

Thomas J. Slaga, W. J. Bracken, G. L. Gleason et al. · PubMed · 1979 · 249 citations

Medicine, Dermatology, Oncology +9

A modified technique for organ culture in vitro

O. A. Trowell · Experimental Cell Research · 1954 · 236 citations

Life Sciences, Cell Biology, Organogenesis +10