Activation of Epidermal Toll-Like Receptor 2 Enhances Tight Junction Function: Implications for Atopic Dermatitis and Skin Barrier Repair

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.4K citations · Full text

Life Sciences, Immunology, Microbiology +13

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

Medicine, Dermatology, Genetics +16

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Adrian Ozinsky, David M. Underhill, Jason D. Fontenot et al. · Proceedings of the National Academy of Sciences · 2000 · 2.1K citations · Full text

Life Sciences, Immunology, Microbiology +17

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

Ralf Schwandner, Roman Dziarski, Holger Wesche et al. · Journal of Biological Chemistry · 1999 · 1.7K citations · Full text

Life Sciences, Immunology, Microbiology +17

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

Mikio Furuse, Masaki Hata, Kyoko Furuse et al. · The Journal of Cell Biology · 2002 · 1.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13