Concepedia

2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization

Nan Zhang, Semiramis Ayral‐Kaloustian, Thai Nguyen, Richard Hernandez, Carl F. Beyer

Bioorganic & Medicinal Chemistry Letters · 2007 · 59 citations · 2 references

Concepts

MedicineMedicinal ChemistryOncologyCancer PharmacologyChemotherapyMolecular OncologyCytotoxic ChemotherapyMicrotubule Assembly InhibitionMicrotubule-associated ProteinsMicrotubule-targeting AgentsInhibition Of Tubulin AssemblyMicrotubule PolymerizationMicrotubule Polymerization InhibitionTubulin Depolymerization InhibitorsTubulin Polymerization Inhibitors

References

2

Synthesis and SAR of [1,2,4]Triazolo[1,5-<i>a</i>]pyrimidines, a Class of Anticancer Agents with a Unique Mechanism of Tubulin Inhibition

Nan Zhang, Semiramis Ayral‐Kaloustian, Thai Nguyen et al. · Journal of Medicinal Chemistry · 2006 · 211 citations

Medicine, Medicinal Chemistry, Pharmacology +13

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Frank Loganzo, Carolyn Discafani, Tami Annable et al. · PubMed · 2003 · 137 citations

Medicine, Medicinal Chemistry, Pharmacology +17