Richard Hernandez

Synthesis and SAR of [1,2,4]Triazolo[1,5-<i>a</i>]pyrimidines, a Class of Anticancer Agents with a Unique Mechanism of Tubulin Inhibition

Nan Zhang, Semiramis Ayral‐Kaloustian, Thai Nguyen et al. · Journal of Medicinal Chemistry · 2006 · 209 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +20

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Frank Loganzo, Carolyn Discafani, Tami Annable et al. · PubMed · 2003 · 137 citations

Microtubule Organization, Pharmacotherapy, Tripeptide Hemiasterlin +18

TTI-237: A Novel Microtubule-Active Compound with <i>In vivo</i> Antitumor Activity

Carl F. Beyer, Nan Zhang, Richard Hernandez et al. · Cancer Research · 2008 · 81 citations · Full text

2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization

Nan Zhang, Semiramis Ayral‐Kaloustian, Thai Nguyen et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 59 citations

Medicinal Chemistry, Pharmaceutical Science, Polymer-drug Conjugate +10

Synthesis and Biological Activity of Analogues of the Antimicrotubule Agent<i>N</i>,β,β-Trimethyl-<scp>l</scp>-phenylalanyl-<i>N</i>-[(1<i>S</i>,2<i>E</i>)-3-carboxy-1-isopropylbut-2-enyl]-<i>N</i>¹,3-dimethyl-<scp>l</scp>-valinamide (HTI-286)

Arie Zask, Gary H. Birnberg, Katherine Cheung et al. · Journal of Medicinal Chemistry · 2004 · 48 citations · Full text

Bioorganic Chemistry, Antiparasitic Agent, Novel Analogues +19