Concepedia

Decreased Galectin-9 and Increased Tim-3 Expression Are Related to Poor Prognosis in Gastric Cancer

Jing Jiang, Meishan Jin, Fei Kong, Donghui Cao, Hongxi Ma, Zhifang Jia, Yinping Wang, Jian Suo, Xueyuan Cao

PLoS ONE · 2013 · 174 citations · 31 references

DOIFull text

Open access

Abstract

The results suggest that expression of Gal-9 and Tim-3 in tumor cells may be a potential, independent prognostic factor for patients with gastric cancer. Gal-9 and TIM-3 may play an important part in the gastric carcinogenesis.

References

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Global cancer transitions according to the Human Development Index (2008–2030): a population-based study

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

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Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

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Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells

Ana C. Anderson, David E. Anderson, Lisa Bregoli et al. · Science · 2007 · 696 citations

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