Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

B Millauer, Susanne Wizigmann-Voos, Harald Schnürch et al. · Cell · 1993 · 1.9K citations

Life Sciences, Cell Biology, Developmental Biology +16

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

Bruce I. Terman, Maureen Dougher-Vermazen, Miguel E. Carrion et al. · Biochemical and Biophysical Research Communications · 1992 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +14

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

Renata Pasqualini, Erkki Koivunen, Renate Kain et al. · PubMed · 2000 · 867 citations

Medicine, Oncology, Pharmacology +16

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee et al. · Nature Medicine · 2001 · 731 citations

Medicine, Cancer Biology, Molecular Biology +14

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Ny Sin, Lihao Meng, Margaret Q. W. Wang et al. · Proceedings of the National Academy of Sciences · 1997 · 627 citations

Medicine, Oncology, Pharmacology +13