Concepedia

Pulsed High-Intensity Focused Ultrasound Enhances Apoptosis and Growth Inhibition of Squamous Cell Carcinoma Xenografts with Proteasome Inhibitor Bortezomib

Jason A. Poff, Clint Allen, Bryan Traughber, Aric Colunga, Jianwu Xie, Zhong Chen, Bradford J. Wood, Carter Van Waes, King C. Li, Victor Frenkel

Radiology · 2008 · 60 citations · 19 references

DOIFull text

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Abstract

Treatment of tumors with pulsed HIFU lowered the threshold level for efficacy of bortezomib, resulting in significant tumor cytotoxicity and growth inhibition at lower dose levels.

References

19

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

Julian Adams, Vito J. Palombella, Edward A. Sausville et al. · PubMed · 1999 · 1.5K citations

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Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

Teru Hideshima, Constantine S. Mitsiades, Masaharu Akiyama et al. · Blood · 2003 · 568 citations · Full text

Pulsed-High Intensity Focused Ultrasound and Low Temperature–Sensitive Liposomes for Enhanced Targeted Drug Delivery and Antitumor Effect

Sergio Dromi, Victor Frenkel, Alfred Chun Shui Luk et al. · Clinical Cancer Research · 2007 · 494 citations · Full text

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

John B. Sunwoo, Zhong Chen, Guo‐Chung Dong et al. · PubMed · 2001 · 479 citations

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Anti-Inflammatory Effect of Heat Shock Protein Induction Is Related to Stabilization of IκBα Through Preventing IκB Kinase Activation in Respiratory Epithelial Cells

Chul‐Gyu Yoo, Seunghee Lee, Choon-Taek Lee et al. · The Journal of Immunology · 2000 · 261 citations · Full text

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