Concepedia

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

Alexis Dumortier, André Durham, Matteo Piazza, Sophie Vauclair, Ute Koch, Gisèle Ferrand, Isabel Ferrero, Shadmehr Demehri, Lynda L. Song, Andrew G. Farr,

PLoS ONE · 2010 · 161 citations · 60 references

DOIFull text

Open access

Abstract

Our data demonstrate a critical role for Notch in repressing TSLP production in keratinocytes, thereby maintaining integrity of the skin and the hematopoietic system.

References

60

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

Vassili Soumelis, Pedro A. Reche, Holger Kanzler et al. · Nature Immunology · 2002 · 2.1K citations

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Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

Yan Zheng, Dimitry M. Danilenko, Patricia Valdez et al. · Nature · 2006 · 1.8K citations

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

Jacques J. Peschon, Philip Morrissey, Kenneth H. Grabstein et al. · The Journal of Experimental Medicine · 1994 · 1.6K citations · Full text

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Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Freddy Radtke, Anne E. Wilson, Gerlinde Stark et al. · Immunity · 1999 · 1.4K citations · Full text

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Notch1 functions as a tumor suppressor in mouse skin

Michaël Nicolas, Anita Wolfer, Kenneth Raj et al. · Nature Genetics · 2003 · 968 citations · Full text

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