Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

Armin Lahm, Chantal Paolini, Michele Pallaoro, +11

Proceedings of the National Academy of Sciences

Histone ModificationsHdac InhibitorsEpigenetic ChangeMolecular BiologyChemical Biology +16

Transcription factor RORα is critical for nuocyte development

See Heng Wong, Jennifer A. Walker, Helen E. Jolin, +12

Nature Immunology

Transcription Factor RorαTranscriptional RegulationTranscription FactorsDevelopmental BiologyGenetics +5

Signalling strength determines proapoptotic functions of STING

Muhammet F. Gülen, Ute Koch, Simone M. Haag, +5

Nature Communications

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Ute Koch, Emma Fiorini, Rui Benedito, +7

The Journal of Experimental Medicine

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

Luca Pellegrinet, Verónica Rodilla, Zhenyi Liu, +7

Gastroenterology

Cell LineageDevelopmental BiologySignal TransductionCell RegulationMedicine +5

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Ivan Maillard, Ute Koch, Alexis Dumortier, +8

Cell stem cell

Developmental BiologyCanonical Notch SignalingMedicineStem Cell MobilizationAdult Stem Cell +6

Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis

Ute Koch, Anne Wilson, Monica Cobas, +3

Blood

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

Ute Koch, Tyler A Lacombe, Dianne Holland, +4

Immunity

Lineage PlasticitySignal TransductionGeneticsT-regulatory CellT/b Lineage Decision +5

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

Jie Gao, Stephanie Graves, Ute Koch, +9

Cell stem cell

Developmental BiologyHedgehog SignalingMedicineStem Cell MobilizationAdult Stem Cell +5

Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation

Valérie Besseyrias, Emma Fiorini, Lothar J. Strobl, +7

The Journal of Experimental Medicine