Concepedia

Synthesis and cytotoxic activity of novel 2,6-disubstituted-4-mor-pholinothieno[3,2-d]pyrimidines as potent anti-tumor agents

Wu Fu Zhu, Xin Zhai, Sai Li, Yun Cao, Ping Gong, Ya Jing Liu

Chinese Chemical Letters · 2012 · 25 citations · 9 references

DOI

Concepts

References

9

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

Teemu T. Junttila, Robert W. Akita, Kathryn L. Parsons et al. · Cancer Cell · 2009 · 831 citations · Full text

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The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 746 citations · Full text

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PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

Patricia J. Rohan, Paula Davis, Christopher A. Moskaluk et al. · Science · 1993 · 294 citations

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Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

Masahiko Hayakawa, Hiroyuki Kaizawa, Hiroyuki Moritomo et al. · Bioorganic & Medicinal Chemistry · 2006 · 195 citations

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Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

Abdel-Rahman B.A. El-Gazzar, Hoda A. R. Hussein, Hend N. Hafez · Acta Pharmaceutica · 2007 · 99 citations · Full text

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