How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

A. De Léan, Jeffrey M. Stadel, Robert J. Lefkowitz · Journal of Biological Chemistry · 1980 · 1.6K citations · Full text

Medicine, Biochemistry, Pharmacology +17

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

Philip Bradley, G. Engel, W. Feniuk et al. · Neuropharmacology · 1986 · 1.3K citations

Medicine, Neuroscience, Pharmacology +12

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

Daniël Hoyer, G. Engel, Hans O. Kalkman · European Journal of Pharmacology · 1985 · 577 citations

Life Sciences, Neuroscience, Pharmacology +13

Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites

Daniël Hoyer, Ángel Pazos, A. Probst et al. · Brain Research · 1986 · 386 citations

Life Sciences, Neuroscience, Pharmacology +15

GR43175, a selective agonist for the 5‐HT₁‐like receptor in dog isolated saphenous vein

P.P.A. Humphrey, W. Feniuk, M.J. Perren et al. · British Journal of Pharmacology · 1988 · 300 citations · Full text

Medicine, Pharmacology, General Pharmacology +13