Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G 2 arrest

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

Dna Damage, Chemoprevention Strategy, Apoptosis +17

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz, Beverly Plunkett, William Walsh et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations · Full text

Tumor Biology, Genome Instability, Wild-type P53 +15

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

Ulrich Strausfeld, Jean‐Claude Labbé, Didier Fesquet et al. · Nature · 1991 · 578 citations

Protein Function, Signal Transduction, Cell Regulation +10

p53 mutations increase resistance to ionizing radiation.

Jae Myeong Lee, Alan Bernstein · Proceedings of the National Academy of Sciences · 1993 · 570 citations · Full text

Mutant P53, Radiation Effects, Radiation Medicine +13

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

Saijun Fan, M L Smith, D J Rivet et al. · PubMed · 1995 · 497 citations

Breast Oncology, Cell Death, Pathology +16