Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists

9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

H. J. Schaeffer, Lilia M. Beauchamp, P de Miranda et al. · Nature · 1978 · 1.1K citations

Life Sciences, Biology, Microbiology +8

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

Carol Parr, Daniel M. Sullivan, Anthony M. Paradiso et al. · Proceedings of the National Academy of Sciences · 1994 · 413 citations

Life Sciences, Pharmacology, Pharmacotherapy +13

Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one

János Ludwig, Fritz Eckstein · The Journal of Organic Chemistry · 1989 · 376 citations

Natural Sciences, Biochemistry, Chemistry +5

Antagonists of the Platelet P<i>_2T</i> Receptor:  A Novel Approach to Antithrombotic Therapy

Anthony H. Ingall, John Dixon, Andrew Bailey et al. · Journal of Medicinal Chemistry · 1999 · 285 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

Ying‐Chih Cheng, Ginger E. Dutschman, Kenneth F. Bastow et al. · Journal of Biological Chemistry · 1987 · 227 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15