Failure of dietary oltipraz to inhibit benzo[α]pyrene-induced lung tumorigenesis in strain a mice

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

Thomas W. Kensler, Patricia A. Egner, Patrick M. Dolan et al. · PubMed · 1987 · 242 citations

Pharmacy, Pharmacology, Toxicology +14

Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.

Iain G. C. Robertson, Claes Guthenberg, Bengt Mannervik et al. · PubMed · 1986 · 168 citations

Life Sciences, Biochemistry, Bioisosterism +14

Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.

Bill D. Roebuck, Y L Liu, Adrianne E. Rogers et al. · PubMed · 1991 · 164 citations

Pharmacy, Pharmacology, Toxicology +16

Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats

Zuyu Guo, Theresa J. Smith, Erjia Wang et al. · Carcinogenesis · 1992 · 163 citations

Medicine, Pharmacology, Toxicology +13

Biochemical effects of dithiolthiones

Sherry S. Ansher, Patrick Dolan, Ernest Bueding · Food and Chemical Toxicology · 1986 · 162 citations

Life Sciences, Biochemistry, Pharmacology +11