A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian, Hubing Shi, Qi Wang et al. · Nature · 2010 · 2.2K citations

Medicine, Cancer Biology, Oncology +11

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 2K citations

Medicine, Cancer Biology, Oncology +16

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Eric J. Brown, David Baltimore · Genes & Development · 2000 · 944 citations · Full text

Life Sciences, Developmental Biology, Genetics +17

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

Mark O’Driscoll, Víctor L. Ruiz‐Pérez, C. Geoffrey Woods et al. · Nature Genetics · 2003 · 778 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16