EpiSIM: simulation of multiple epistasis, linkage disequilibrium patterns and haplotype blocks for genome-wide interaction analysis

Haploview: analysis and visualization of LD and haplotype maps

Jeffrey C. Barrett, Ben Fry, Julian Maller et al. · Bioinformatics · 2004 · 14.7K citations · Full text

Life Sciences, Biostatistics, Genetics +17

Multifactor-Dimensionality Reduction Reveals High-Order Interactions among Estrogen-Metabolism Genes in Sporadic Breast Cancer

Marylyn D. Ritchie, Lance W. Hahn, Nady Roodi et al. · The American Journal of Human Genetics · 2001 · 1.9K citations · Full text

Medicine, Genetics, Oncology +8

Personal genomes: The case of the missing heritability

Brendan A. Maher · Nature · 2008 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +8

BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies

Xiang Wan, Can Yang, Qiang Yang et al. · The American Journal of Human Genetics · 2010 · 517 citations · Full text

Life Sciences, Bioinformatics, Genetics +5

Bayesian inference of epistatic interactions in case-control studies

Yu Zhang, Jun S. Liu · Nature Genetics · 2007 · 484 citations

Public Health, Biostatistics, Bayesian Biostatistics +14