Epistasis

Epistasis is the phenomenon in which the effect of one gene is influenced or masked by one or more other genes at different loci, resulting in a non-additive contribution to the phenotype. As a concept and field of study, it investigates non-allelic gene interactions and their collective impact on phenotypic variation, which is critical for understanding the complex genetic architecture underlying traits and diseases.

306

Publications

26.3K

Citations

922

Authors

422

Institutions

Publications per year

2017–2026

Parents

Genetics

Publications

306

The separation of epistatic from additive and dominance variation in generation means

B I Hayman · Heredity · 1958 · 736 citations · Full text

Biology, Pattern Formation, Medicine +9

Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid

Shan Yu, J. X. Li, Chao Xu et al. · Proceedings of the National Academy of Sciences · 1997 · 729 citations · Full text

Plant Genetics, Genetics, Total Variation +17

The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases

Jason H. Moore · Human Heredity · 2003 · 724 citations

Molecular Epidemiology, Disease Etiology, Genetics +25

AN EXTENSION OF THE CONCEPT OF PARTITIONING HEREDITARY VARIANCE FOR ANALYSIS OF COVARIANCES AMONG RELATIVES WHEN EPISTASIS IS PRESENT

C. Clark Cockerham · Genetics · 1954 · 637 citations · Full text

Linkage Disequilibrium, Genotype-phenotype Association, Molecular Ecology +14

A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility

Jason H. Moore, Joshua C. Gilbert, Chia‐Ti Tsai et al. · Journal of Theoretical Biology · 2006 · 602 citations

Genetics, Genetic Epidemiology, Disease Gene Identification +18

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Authors

922

Leading researchers in Epistasis. Counts cover only their work on this concept, not their overall record.

	Publications	Citations	H-Index
CJ Charles J. Goodnight University of Vermont	8	795	8
JH Jason H. Moore Dartmouth College	8	1.9K	8
JM James M. Cheverud Washington University in St. Louis	7	424	7
MJ Michael J. Wade Indiana University Bloomington	7	470	7
GP Günter P. Wagner Yale University	6	339	6

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Institutions

422

Leading universities and research organizations in Epistasis. Counts cover only their work on this concept, not their overall record.

	Publications	Citations	H-Index
Harvard University Cambridge, United States	28	4.6K	12
Stanford University Stanford, United States	26	2K	10
Washington University in St. Louis St Louis, United States	19	2K	10
University of British Columbia Vancouver, Canada	17	1.2K	10
North Carolina State University Raleigh, United States	13	1.2K	10

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Venues

Leading journals and conferences in Epistasis. Counts cover only their publications on this concept, not their overall record.

	Publications	Citations	H-Index
Evolution	36	3K	26
Genetics	23	3.1K	21
PLoS Genetics	14	1.1K	14
PLoS ONE	10	257	10
Theoretical Population Biology	11	566	10

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