Concepedia

Multitargeted Effects of Hangeshashinto for Treatment of Chemotherapy-Induced Oral Mucositis on Inducible Prostaglandin E2 Production in Human Oral Keratinocytes

Toru Kono, Atsushi Kaneko, Chinami Matsumoto, Chika Miyagi, Katsuya Ohbuchi, Yasuharu Mizuhara, Kanako Miyano, Yasuhito Uezono

Integrative Cancer Therapies · 2014 · 81 citations · 39 references

DOIFull text

Open access

Abstract

These lines show that HST includes several PGE2-regulating ingredients that have different mechanisms and can function as a multicomponent and multitarget agent for treatment of COM, indicating that HST may be beneficial in a new medical strategy for COM treatment.

References

39

Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells

Hongmiao Sheng, Jinyi Shao, M. Kay Washington et al. · Journal of Biological Chemistry · 2001 · 649 citations · Full text

PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

Nataša Obermajer, Ravikumar Muthuswamy, Kunle Odunsi et al. · Cancer Research · 2011 · 443 citations · Full text

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

Hyun Woo Jeong, Kuan Chi Hsu, Joo-Won Lee et al. · American Journal of Physiology-Endocrinology and Metabolism · 2009 · 439 citations

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The effect of extracts from ginger rhizome on inflammatory mediator production

R. Clark Lantz, G.J. Chen, M. Sarihan et al. · Phytomedicine · 2006 · 306 citations

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Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide11Abbreviations: NO, nitric oxide; iNOS, inducible nitricoxide synthase; COX-2, cyclooxygenase-2; PGE2,prostaglandin E2; MTT,3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, LPS,lipopolysaccharide; NLA, N-nitro-l-arginine; andL-NAME, N-nitro-l-arginine methyl ester.

Yen‐Chou Chen, Shing‐Chuan Shen, Lih-Geeng Chen et al. · Biochemical Pharmacology · 2001 · 270 citations

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