Concepedia

Thrombolytic Toxicity: Blood Brain Barrier Disruption in Human Ischemic Stroke

Chelsea S. Kidwell, Larry Latour, Jeffrey L. Saver, Jeffry R. Alger, Sidney Starkman, Gary Duckwiler, Reza Jahan, Fernando Viñuela, Dong‐Wha Kang, Steven Warach

Cerebrovascular Diseases · 2008 · 119 citations · 16 references

DOI

Abstract

This is the first study in humans providing supportive evidence of the neurovascular toxic effects of thrombolytics and suggests that HARM may be used as a biomarker of blood brain barrier disruption in future research of acute stroke therapies.

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