The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

K A Reimer, J. E. Lowe, Margaret M. Rasmussen et al. · Circulation · 1977 · 1.9K citations · Full text

Medicine, Cardiology, Clinical Cardiology +13

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

Marc Hoylaerts, D.C. Rijken, H.R. Lijnen et al. · Journal of Biological Chemistry · 1982 · 1.3K citations · Full text

Life Sciences, Biochemistry, Enzymology +10

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

Diane Pennica, William E. Holmes, William J. Kohr et al. · Nature · 1983 · 1.2K citations

Life Sciences, Microbiology, Molecular Biology +14

The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow.

K A Reimer, Robert B. Jennings · PubMed · 1979 · 1.2K citations

Medicine, Cardiology, Cell Biology +12

Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris.

P. Rentrop, H. Blanke, K. R. Karsch et al. · Circulation · 1981 · 802 citations

Medicine, Cardiology, Internal Medicine +14