Concepedia

Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer

Charlotte E. Edling, Federico Selvaggi, Richard Buus, Tania Maffucci, Pierluigi Di Sebastiano, Helmut Friess, Paolo Innocenti, Hemant M. Kocher, Marco Falasca

Clinical Cancer Research · 2010 · 99 citations · 25 references

DOI

Abstract

These data represent the first identification of a tumor-specific accumulation of the PI3K isoform p110γ in human cancer. Further, our results signify a critical role for PI3K/p110γ in pancreatic cancer, and we hypothesize that PI3K/p110γ overexpression is a key event in the disease progression.

References

25

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

, , +12

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

, , +15

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

Carmen Guerra, Alberto J. Schuhmacher, Marta Cañamero et al. · Cancer Cell · 2007 · 1.2K citations · Full text

, , +10

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

Asim Khwaja · The EMBO Journal · 1997 · 1K citations · Full text

, , +15

Progression model for pancreatic cancer.

Ralph H. Hruban, Michael Goggins, Jason L. Parsons et al. · PubMed · 2000 · 868 citations

, , +11