Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

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Inflammation, Cytokine, Transcriptional Regulation +13

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine · 2007 · 2.5K citations

Oxysterol, Biochemistry, Cytotoxic Oxygen Radicals +8

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

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MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

The Lancet · 2002 · 1.4K citations

Nutrition, Cardiovascular Disease, Health Policy +7

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

Junichi Sadoshima, Yuhui Xu, Henry S. Slayter et al. · Cell · 1993 · 1.3K citations

Stretch-induced Hypertrophy, Cardiac Muscle, Cardiomyopathy +11