Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

Junichi Sadoshima, Seigo Izumo · Circulation Research · 1993 · 1.4K citations · Full text

Life Sciences, Pharmacology, Physiology +6

Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial Infarction

Marc A. Pfeffer, Gervasio A. Lamas, Douglas E. Vaughan et al. · New England Journal of Medicine · 1988 · 1.1K citations

Medicine, Cardiology, Internal Medicine +12

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

Seigo Izumo, B Nadal-Ginard, Vijak Mahdavi · Proceedings of the National Academy of Sciences · 1988 · 870 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

Junichi Sadoshima, Seigo Izumo · The EMBO Journal · 1993 · 668 citations

Life Sciences, Cell Biology, Physiology +17

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

Junichi Sadoshima, L. Jahn, Toshiyuki Takahashi et al. · Journal of Biological Chemistry · 1992 · 606 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +8