The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

Genome Instability, Anticancer Drug Camptothecin, Intracellular Target +13

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

Beppino C. Giovanella, John S. Stehlin, Monroe E. Wall et al. · Science · 1989 · 645 citations

Tumor Biology, Gastrointestinal Oncology, Human Colon Cancer +14

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

Peter J. Houghton, Pamela J. Cheshire, James D. Hallman et al. · Cancer Chemotherapy and Pharmacology · 1995 · 406 citations

Human Tumors, Oncology, Medicine +9

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

Eric K. Rowinsky, L B Grochow, Carolyn B. Hendricks et al. · Journal of Clinical Oncology · 1992 · 358 citations