Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

Beppino C. Giovanella, John S. Stehlin, Monroe E. Wall et al. · Science · 1989 · 647 citations

Medicine, Oncology, Pharmacology +15

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

William D. Kingsbury, Jeffrey C. Boehm, Dalia R. Jakas et al. · Journal of Medicinal Chemistry · 1991 · 516 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

N Masuda, M. Fukuoka, Y Kusunoki et al. · Journal of Clinical Oncology · 1992 · 452 citations

Medicine, Oncology, Pharmacology +8

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

M. Fukuoka, H Niitani, Atsushi Suzuki et al. · Journal of Clinical Oncology · 1992 · 435 citations

Medicine, Oncology, Pharmacology +16