Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

Beverly H. Koller, Philippa Marrack, John W. Kappler et al. · Science · 1990 · 881 citations

Life Sciences, Genetics, Immunology +17

Mice lacking MHC class II molecules

Dominic Cosgrove, David W. Gray, Andrée Dierich et al. · Cell · 1991 · 850 citations · Full text

Life Sciences, Immunology, Molecular Biology +10

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

Amin Rahemtulla, Wai‐Ping Fung‐Leung, Marco W. Schilham et al. · Nature · 1991 · 685 citations

Life Sciences, Developmental Biology, Immunology +17

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Hung Sia Teh, Paweł Kisielow, Bernadette Scott et al. · Nature · 1988 · 663 citations

Life Sciences, Cell Biology, Immunology +16

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

Michael J. Grusby, Randall S. Johnson, Virginia E. Papaioannou et al. · Science · 1991 · 663 citations

Life Sciences, Genetics, Immunology +17