Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M S Brown, J L Goldstein · Journal of Lipid Research · 1980 · 1.2K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

Modulation of type M ₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

Werner Zwerschke, Sybille Mazurek, Paola Massimi et al. · Proceedings of the National Academy of Sciences · 1999 · 256 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation

Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee et al. · Biochemical Journal · 2003 · 197 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.

Toshiyuki Kusama, Mutsuko Mukai, Teruo Iwasaki et al. · PubMed · 2001 · 187 citations

Medicine, Oncology, Pharmacology +16

Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

William A. Maltese, R Defendini, R. A. Green et al. · Journal of Clinical Investigation · 1985 · 125 citations · Full text

Medicine, Biochemistry, Pharmacology +14