Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The Universal Protein Resource (UniProt)

Amos Bairoch · Nucleic Acids Research · 2004 · 3.8K citations · Full text

Life Sciences, Bioinformatics, Toxicology +16

Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

Suraj Peri, J. Daniel Navarro, Ramars Amanchy et al. · Genome Research · 2003 · 1.1K citations · Full text

Life Sciences, Bioinformatics, Systems Biology +17

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Daniel R. Knighton, Jianhua Zheng, Lynn F. Ten Eyck et al. · Science · 1991 · 963 citations

Life Sciences, Biochemistry, Molecular Biology +17

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

Bruce E. Kemp, D J Graves, E. Benjamini et al. · Journal of Biological Chemistry · 1977 · 849 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12