STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

Seiji Okada, Masaya Nakamura, Hiroyuki Katoh et al. · Nature Medicine · 2006 · 984 citations

Medicine, Neurobiology, Neuroscience +17

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

Julia Herrmann, Tetsuya Imura, Bingbing Song et al. · Journal of Neuroscience · 2008 · 948 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Naftaly Meydan, T Grunberger, Harjit Dadi et al. · Nature · 1996 · 912 citations

Medicine, Hematology, Pharmacology +9

Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3

Katherine E. Cole, Christine A. Strick, Timothy Paradis et al. · The Journal of Experimental Medicine · 1998 · 879 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida et al. · Proceedings of the National Academy of Sciences · 2007 · 743 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14