Concepedia

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (−/−) mice: A test of the `guardian of the genome' hypothesis in the Big Blue® transgenic mouse mutation detection system

Victoria L. Buettner, Hiroshi Nishino, Jan Haavik, Antje Knöll, Kathleen A. Hill, Steve S. Sommer

Mutation research. Fundamental and molecular mechanisms of mutagenesis · 1997 · 43 citations · 30 references

DOI

Concepts

References

30

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

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Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

, , +14

Mutations in the p53 gene occur in diverse human tumour types

Janice Nigro, Suzanne J. Baker, Antonette C. Preisinger et al. · Nature · 1989 · 2.8K citations · Full text

, , +12

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz, Beverly Plunkett, William Walsh et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

, , +15

A cancer family syndrome in twenty-four kindreds.

Frederick P. Li, Joseph F. Fraumeni, J. J. Mulvihill et al. · PubMed · 1988 · 1.3K citations

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