Concepedia

Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria

Piera Pasinelli, Mary Elizabeth Belford, Niall J. Lennon, Brian J. Bacskai, Bradley T. Hyman, Davide Trotti, Robert H. Brown

Neuron · 2004 · 495 citations · 37 references

DOIFull text

Open access

Concepts

References

37

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

, , +14

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip C. Wong, Carlos A. Pardo, David Borchelt et al. · Neuron · 1995 · 1.4K citations

, , +17

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

Xiao-Ming Yin, Zoltán N. Oltvai, Stanley J. Korsmeyer · Nature · 1994 · 1.3K citations

, , +5

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Lucie Bruijn, Megan K. Houseweart, Shinsuke Kato et al. · Science · 1998 · 1.2K citations

, , +17

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

Tony L. Parkes, Andrew Elia, D.R. Dickinson et al. · Nature Genetics · 1998 · 869 citations

, , +14