The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral® or with RAD

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

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Life Sciences, Immunology, Pharmacology +15

SDZ RAD, A NEW RAPAMYCIN DERIVATIVE

W. Schüler, Richard Sedrani, Sylvain Cottens et al. · Transplantation · 1997 · 538 citations

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Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi, Toshiyuki Kohara, Noriyoshi Nakao et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 308 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

Seiichi Suzuki, Shin Enosawa, Toshihiro Kakefuda et al. · Transplantation · 1996 · 292 citations

Medicine, Cell Biology, Pharmacology +16

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

Yoshiki Yanagawa, Kunio Sugahara, Hirotoshi Kataoka et al. · The Journal of Immunology · 1998 · 262 citations · Full text

Life Sciences, Immunology, Pharmacology +16