Kunitomo Adachi

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi, Toshiyuki Kohara, Noriyoshi Nakao et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 308 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Masatoshi Kiuchi, Kunitomo Adachi, Toshiyuki Kohara et al. · Journal of Medicinal Chemistry · 2000 · 218 citations

Pharmacy, Immunology, Medicinal Chemistry +13

Enantioselective synthesis of the carbocyclic nucleosides (-)-aristeromycin and (-)-neplanocin A by a chemicoenzymatic approach

Masafumi Arita, Kunitomo Adachi, Yukishige Ito et al. · Journal of the American Chemical Society · 1983 · 193 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity

Tetsuro Fujita, Masahiko Yoneta, Ryoji Hirose et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 103 citations

Medicine, Immunology, Pharmacology +10

FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.

Kunitomo Adachi, Kenji Chiba · PubMed · 2007 · 84 citations

Medicine, Immunology, Pharmacology +13