Toshiyuki Kohara

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi, Toshiyuki Kohara, Noriyoshi Nakao et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 308 citations

Medicinal Chemistry, Novel Immunosuppressant, Biochemistry +8

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Masatoshi Kiuchi, Kunitomo Adachi, Toshiyuki Kohara et al. · Journal of Medicinal Chemistry · 2000 · 217 citations

Medicinal Chemistry, Lead Compound 3, Bioorganic Chemistry +13

Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720

Masatoshi Kiuchi, Kunitomo Adachi, Toshiyuki Kohara et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 58 citations

Bioorganic Chemistry, Biochemistry, 2,2-Disubstituted 2-Aminoethanols +7

2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors

Kenji Fukunaga, Fumiaki Uehara, Keiichi Aritomo et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 32 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +13

Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease

Kenji Fukunaga, Daiki Sakai, Kazutoshi Watanabe et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 31 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Alzheimer's Disease +11