Klotho is a target gene of PPAR-γ

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

Suppression of Aging in Mice by the Hormone Klotho

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text

Education, Endocrinology, Genetics +17

Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

You Fei Guan, Chuan‐Ming Hao, Dae Ryong et al. · Nature Medicine · 2005 · 602 citations

Medicine, Nephrology, Pharmacology +16

Severely Reduced Production of Klotho in Human Chronic Renal Failure Kidney

Noritoshi Koh, Toshihiko Fujimori, Shuhei Nishiguchi et al. · Biochemical and Biophysical Research Communications · 2001 · 494 citations

Medicine, Biochemistry, Nephrology +9

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Andrea L. Hevener, Jerrold M. Olefsky, Donna Reichart et al. · Journal of Clinical Investigation · 2007 · 454 citations · Full text

Medicine, Endocrinology, Pharmacology +17