Cathepsin D-mediated proteolysis of apolipoprotein E: Possible role in Alzheimer’s disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

Life Sciences, Genetics, Neurology +17

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

Suzanne S. Mirra, Albert Heyman, Daniel W. McKeel et al. · Neurology · 1991 · 5.1K citations

Medicine, Genetics, Neurology +17

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Diagnosis of Alzheimer's Disease

Zaven S. Khachaturian · Archives of Neurology · 1985 · 2.5K citations

Medicine, Neurology, Psychiatry +13

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Warren J. Strittmatter, Karl H. Weisgraber, Daoyuan Huang et al. · Proceedings of the National Academy of Sciences · 1993 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +16