IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.8K citations

Developmental Biology, Autoimmune Disease, Lymphocyte Development +13

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5K citations · Full text

Inflammation, Cytokine, Lymphocyte Development +9

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature · 2006 · 3K citations

Developmental Biology, Th17 Lineage, Cell Proliferation +3

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

David Fiorentino, Albert Zlotnik, Paulo Vieira et al. · The Journal of Immunology · 1991 · 1.9K citations · Full text

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

Mandy J. McGeachy, Kristian Sass Bak‐Jensen, Yi Chen et al. · Nature Immunology · 2007 · 1.5K citations

Inflammation, Cytokine, T Cells +8