Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Catherine Postic, Masakazu Shiota, Kevin D. Niswender et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

M.Dodson Michael, Rohit Kulkarni, Catherine Postic et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Medicine, Cell Biology, Endocrinology +17

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Iichiro Shimomura, Morihiro Matsuda, Robert E. Hammer et al. · Molecular Cell · 2000 · 832 citations

Life Sciences, Biochemistry, Endocrinology +16

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

RA DeFronzo · Diabetes reviews · 1997 · 674 citations

Medicine, Genetics, Molecular Genetics +12