Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

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Structural basis for ligand promiscuity in cytochrome P450 3A4

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Terfenadine-Ketoconazole Interaction

Peter K. Honig · JAMA · 1993 · 658 citations

Medicine, Pharmacokinetics, Pharmacology +15

The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

Mary Ann Jordan, Kathryn Kamath, Tapas Manna et al. · Molecular Cancer Therapeutics · 2005 · 494 citations

Medicine, Oncology, Pharmacology +17