Ion-channel assay technologies: quo vadis?

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Electrical Engineering, Engineering, Cell-free Membrane Patches +7

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 6.9K citations · Full text

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

D. Doyle, João H. Morais‐Cabral, Richard A. Pfuetzner et al. · Science · 1998 · 6.8K citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +10

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Long Qt Syndrome, Cardiomyopathy, Genetics +9