Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Biochemistry, Pharmacology +10

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Toru Kino, Hiroshi Hatanaka, Susumu Miyata et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Immunology, Pharmacology +9

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

John J. Siekierka, Shirley H.Y. Hung, Martin Poe et al. · Nature · 1989 · 1K citations

Life Sciences, Biochemistry, Pharmacology +9

A Comparison of Tacrolimus (FK 506) and Cyclosporine for Immunosuppression in Liver Transplantation

The U.S. Multicenter FK Liver Study Group · New England Journal of Medicine · 1994 · 922 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

Francis J. Dumont, Mary Jo Staruch, Sam L. Koprak et al. · The Journal of Immunology · 1990 · 609 citations

Life Sciences, Immunology, Pharmacology +8