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Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain

Makoto Kawai, Kazuo Ando, Yukari Matsumoto, Isao Sakurada, Masako Hirota, Hiroshi Nakamura, Atsuko Ohta, Masaki Sudo, Kazunari Hattori, Tadashi Takashima,

Bioorganic & Medicinal Chemistry Letters · 2007 · 15 citations · 15 references

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References

15

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

Anthony H. Dickenson, Ann F. Sullivan · Neuropharmacology · 1987 · 839 citations

, , +16

Glutamate in CNS disorders as a target for drug development: an update

Chris G. Parsons, Wojciech Danysz, G. Quack · Drug News & Perspectives · 1998 · 447 citations

, , +17

High‐dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia

Kristine A. Nelson, Karen M. Park, Elaine Robinovitz et al. · Neurology · 1997 · 358 citations

, , +17

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

S. Boyce, A. C. Wyatt, J.K. Webb et al. · Neuropharmacology · 1999 · 338 citations

, , +17

Induction of long‐term potentiation at spinal synapses by noxious stimulation or nerve injury

Jürgen Sandkühler, Xian‐Guo Liu · European Journal of Neuroscience · 1998 · 315 citations · Full text

, , +9