Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

Shinya Omoto, Valentina Speranzini, Takashi Hashimoto, +8

Scientific Reports

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

Takeshi Noshi, Mitsutaka Kitano, K. Taniguchi, +17

Antiviral Research

Vitro CharacterizationBiochemistryNatural SciencesImmunologyAntiviral Drug Development +9

Efficacy of Corticosteroids in the Treatment of Community-Acquired Pneumonia Requiring Hospitalization

Katsunaka Mikami, Masaru Suzuki, Hiroshi Kitagawa, +10

Lung

Respiratory InfectionSepsisInfectious Respiratory DiseasePulmonary MedicineMedicine +1

Identification of genes involved in growth autonomy of hematopoietic cells by analysis of factor-independent mutants

Carol Stocking, C. Löliger, Makoto Kawai, +3

Cell

Cell LineageCell DivisionHematopoietic CellsGeneticsFactor-independent Mutants +11

In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide

Yuewei Zhang, K. Takahashi, G Z Jiang, +3

Infection and Immunity

Dna DamageImmunotoxicologyMedicineVivo AdministrationApoptosis +12

Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Keita Fukao, Yoshinori Ando, Takeshi Noshi, +7

PLoS ONE

VaccinationAllergyVirus TiterBaloxavir MarboxilMedicine +9

In vivo production of heat shock protein in mouse peritoneal macrophages by administration of lipopolysaccharide

Yuewei Zhang, K. Takahashi, G Z Jiang, +4

Infection and Immunity

InflammationHeat Shock ProteinHeat ShockMedicinePathogenesis +13

Localization of Apoptosis (Programmed Cell Death) in Mice by Administration of Lipopolysaccharide

Xian‐min Zhang, Akiko Morikawa, Kazuko Takahashi, +6

Microbiology and Immunology

Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil

K. Taniguchi, Yoshinori Ando, Haruaki Nobori, +12

Scientific Reports

Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease

Masayoshi Miyagawa, Toshiyuki Akiyama, Yoshiyuki Taoda, +11

Journal of Medicinal Chemistry