Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

<i>miR-15</i> and <i>miR-16</i> induce apoptosis by targeting BCL2

Amelia Cimmino, George A. Calin, Muller Fabbri et al. · Proceedings of the National Academy of Sciences · 2005 · 3.5K citations · Full text

Life Sciences, Cancer Biology, Oncology +15

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Jennifer A. Chan, Anna M. Krichevsky, Kenneth S. Kosik · Cancer Research · 2005 · 2.5K citations

Medicine, Cancer Biology, Oncology +17

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

Patrick J. Paddison, Amy A. Caudy, Emily Bernstein et al. · Genes & Development · 2002 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

Yoshimasa Saito, Gangning Liang, Gerda Egger et al. · Cancer Cell · 2006 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Oncology +16

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

Guangchao Sui, Christina Soohoo, El Bachir Affar et al. · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +11