DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

David Roulois, Helen Loo Yau, Rajat Singhania, +9

Cell

Endogenous TranscriptsOncogenic AgentColorectal CancerGenome EditingGene Vector +8

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

Yoshimasa Saito, Gangning Liang, Gerda Egger, +4

Cancer Cell

Tumor BiologyProto-oncogene Bcl6MedicineOncogenic AgentMicrorna Detection +9

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

Xiaojing Yang, Han Han, Daniel D. De Carvalho, +3

Cancer Cell

ChromatinSystems BiologyEpigenetic ChangeDna MethylationEpigenomics +6

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

Keith D. Robertson, É. Uzvölgyi, Gangning Liang, +4

Nucleic Acids Research

Histone ModificationsEpigenetic ChangeGeneticsDna MethylationCancer Biology +20

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

Tina Branscombe Miranda, Connie C. Cortez, Christine B. Yoo, +5

Molecular Cancer Therapeutics

Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements

Gangning Liang, Matilda F. Chan, Yoshitaka Tomigahara, +5

Molecular and Cellular Biology

Histone ModificationsEpigenetic ChangeGeneticsDna MethylationMolecular Biology +18

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome

Gangning Liang, Joy Lin, Vivian Wei, +8

Proceedings of the National Academy of Sciences

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

Theresa K. Kelly, Yaping Liu, Fides D. Lay, +3

Genome Research

ChromatinFunctional GenomicsChromatin StructureChromatin RemodelingNatural Sciences +12

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

Einav Nili Gal‐Yam, Gerda Egger, Leo Iniguez, +7

Proceedings of the National Academy of Sciences

Epigenetic ChangeGeneticsDna MethylationMolecular BiologyEpigenetics +17

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

Carvell T. Nguyen, Daniel J. Weisenberger, Mihaela Velicescu, +4

PubMed

Histone ModificationsHistone H3-lysine 9Epigenetic ChangeGeneticsMolecular Biology +23