RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4gene expression in combination with ETS family proteins

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

Tsukasa Okuda, Jan M. van Deursen, Scott W. Hiebert et al. · Cell · 1996 · 1.9K citations · Full text

Hematological Malignancy, Chromatin, Developmental Biology +8

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Qing Wang, Terryl Stacy, Michael Binder et al. · Proceedings of the National Academy of Sciences · 1996 · 1.2K citations · Full text

Genetics, Immunology, Blood Cell +20

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Woo‐Joo Song, Melanie G. Sullivan, Robert D. Legare et al. · Nature Genetics · 1999 · 1.1K citations

Hematological Malignancy, Thrombosis, Acute Myelogenous Leukaemia +11

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

Qing Wang, Terryl Stacy, Janelle Miller et al. · Cell · 1996 · 623 citations · Full text

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

Motoshi Ichikawa, Takashi Asai, Go Yamamoto et al. · Nature Medicine · 2004 · 575 citations

Hematological Malignancy, Developmental Biology, Medicine +12