Concepedia

Runx1-dependent Differentiation

Runx1-Dependent Differentiation is a molecular mechanism of hematopoietic lineage specification that is distinguished by its reliance on the transcription factor Runx1 to initiate and regulate the developmental commitment of multipotent progenitor cells into defined immune cell lineages.

170

Publications

11.9K

Citations

1.2K

Authors

381

Institutions

Publications per year

2017–2026

46

Parents

Publications

170

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Michael Chen, Tomomasa Yokomizo, Brandon M. Zeigler et al. · Nature · 2009 · 1K citations · Full text

, , +9

Hematopoietic stem cell fate is established by the Notch–Runx pathway

Caroline E. Burns, David Traver, Elizabeth A. Mayhall et al. · Genes & Development · 2005 · 404 citations · Full text

, , +17

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

Vanja Lazarevic, Xi Chen, Jae‐Hyuck Shim et al. · Nature Immunology · 2010 · 370 citations · Full text

, , +13

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

Jacques L. Michaud · Blood · 2002 · 364 citations · Full text

, , +17

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations

Jih‐Luh Tang, Hsin‐An Hou, Chien‐Yuan Chen et al. · Blood · 2009 · 345 citations · Full text

, , +17

1–5 of 170

Authors

1.2K

  1. GL
    Georges Lacaud

    Cancer Research UK Manchester Institute, United Kingdom

    7 publications · 347 citations

    7

    h-index

  2. MS
    Masanobu Satake

    Tohoku University, Japan

    7 publications · 694 citations

    7

    h-index

  3. NA
    Nancy A. Speck

    Dartmouth College, United States

    7 publications · 1.5K citations

    7

    h-index

  4. VK
    Valérie Kouskoff

    Cancer Research UK Manchester Institute, United Kingdom

    6 publications · 319 citations

    6

    h-index

  5. MK
    Mineo Kurokawa

    The University of Tokyo, Japan

    6 publications · 435 citations

    6

    h-index

1–5 of 1.2K

Institutions

381

  1. Harvard University

    Cambridge, United States

    12 h-index

    46 publications

    5.2K citations

  2. The University of Tokyo

    Tokyo, Japan

    10 h-index

    64 publications

    5.2K citations

  3. National Institutes of Health

    Bethesda, United States

    8 h-index

    23 publications

    1.3K citations

  4. Cancer Research UK Manchester Institute

    Manchester, United Kingdom

    7 h-index

    34 publications

    1.5K citations

  5. Leibniz Institute of Virology (LIV)

    Hamburg, Germany

    7 h-index

    30 publications

    1.7K citations

  6. University of California San Diego

    San Diego, United States

    7 h-index

    39 publications

    2.2K citations

  7. National Human Genome Research Institute

    Bethesda, United States

    7 h-index

    19 publications

    925 citations

  8. Tohoku University

    Sendai, Japan

    7 h-index

    23 publications

    1.8K citations

1–8 of 381

Venues

  1. Blood

    40 publications · 3.5K citations

    32

    h-index

  2. Development

    6 publications · 374 citations

    6

    h-index

  3. Leukemia

    5 publications · 247 citations

    5

    h-index

  4. Nature Communications

    5 publications · 367 citations

    5

    h-index

  5. Oncogene

    5 publications · 148 citations

    5

    h-index

1–5